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The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers. Participants in this study will undergo a positron emission tomography PET scan of the brain while performing neuropsychological tests. Some of the tests involve cognitive operations that depend upon the frontal cortex.

Interactions between frontal lobe activation, cognitive behavior, and neuropharmacology will be assessed by measuring regional cerebral blood flow rCBF during treatment with drugs that may affect frontal lobe physiology Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. No one will be excluded or discriminated against on the grounds of race, gender, religion or ethnic background.

Every attempt will be made to include women and minorities in the study population. Children will not be studied because of radiation exposure limits on this group. Normal control subjects will be recruited through the NIH normal volunteer program and through advertisement in the community and primarily through the "Genetic Study" under protocol M An additional control group of non-schizophrenic siblings of patients with schizophrenia will also be recruited from the community and protocol M, A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings.

Control subjects will be matched to the patient groups by age, sex, and handedness. Control subjects with history of psychiatric or neurologic disorders or medical illnesses or surgeries that might have relevance to the investigation of brain physiology will be excluded. Normal subjects taking medications with relevance to cerebral blood flow and metabolism will be excluded from study. Patients with history of neurological illness other than those of interest to the study, or other medical illness or surgery that might have impact on the study of brain physiology, will be excluded.

They will also be studied when they are stabilized on medication; however, no treatment decisions, for inpatients or outpatients, will be based upon this study. Additional neuropsychiatric patients such as those with affective disorder, Parkinson's Disease, special genetic disorders e.

Studies of Frontal Lobe Brain Functioning in Schizophrenia

Patients will be identified by the presence of typical symptoms and signs elicited by history and examination. Diagnoses will conform to accepted diagnostic guidelines where applicable. Such patients will be excluded from study for 1 history of psychiatric or neurologic disorders other than those under investigation, 2 medical illnesses or surgeries that might have relevance to the investigation of brain physiology, 3 current medications that are not under investigation and that have relevance to cerebral blood flow and metabolism, and 4 IQ less than Outpatients may be admitted overnight if necessary or otherwise applicable e.

No cognitively impaired nonschizophrenic subjects are studied in this protocol. For Parkinsons Disease patients, information is obtained from referring physicians, from NIH medical records for participants already enrolled in the NIH system, and by phone from the potential participant. Further assessment is carried out by a neurologist or psychiatrist upon arrival at the NIH.

For Williams syndrome patients, IQ testing is done off-site by a certified clinical neuropsychologist who refers patients for our study and who has followed large numbers of these rare individuals for years. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms x.

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Save this study. Warning You have reached the maximum number of saved studies Studies of Frontal Lobe Brain Functioning in Schizophrenia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. Essai d'un traitement chirurgical de certaines psychoses.

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Frontal lobe disorder

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Leucotomy in England and Wales: — London : Her Majesty's Stationery Office 36 pp. London: Her Majesty's Stationery Office 36 pp. Tucker W. Results of lobotomy. Ward A. The cingular gyrus: area Whitty C. Duffield J. Tow P. Anterior cingulectomy in the treatment of mental disease. Lancet 1 : — Lancet 1: — Yakovlev P. Discussion of: Cassidy, W. Frontal cingulotomy for affective disorders. Personal Communication Discussion of: Cassidy W.

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Not registered? Search Close Advanced Search Help. Thomas Ballantine Jr. Restricted access. All currencies in US Dollar. Rhoton Anatomy Links. PDF Preview. Volume Issue 5 May in Journal of Neurosurgery. Article Information.

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Page Count: — View in gallery Schema of the limbic system. View in gallery Cingulotomy for neuropsychiatric illness. View in gallery Anteroposterior and lateral views of the electrodes in place for creation of a cingulate lesion. View in gallery Cross setion showing plaement of the bilateral cingulate lesions. View in gallery Loyez stain showing destruction of the cingulum bundle and its topographical relations to neighboring structures. View in gallery Status of 40 psychiatric patients after cingulotomy. View raw image Close.